NFL Week 5 Opening Lines Highlighted By Jaguars-Bills In London, Cowboys-49ers on SNF

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The contenders are starting to separate from the pretenders as we enter Week 5 of the NFL season. Buffalo humbled Miami in the Dolphins-Bills shellacking. The undefeated San Francisco 49ers look like a wagon. The Philadelphia Eagles eked past the Washington Commanders to move to 4-0.

Teams on a bye in Week 5: Cleveland Browns, Los Angeles Chargers, Seattle Seahawks, and Tampa Bay Buccaneers. Below are the opening NFL Week 5 spreads as of Monday, October 2 at 8:30 a.m. ET.

NFL Week 5 Lines

Thursday Night Football, 8:15 p.m. ET

Chicago Bears (0-4) at Washington Commanders (2-2)

NFL London game, Sunday at 9:30 a.m. ET

Jacksonville Jaguars (2-2) vs. Buffalo Bills (3-1) at the Tottenham Hotspur Stadium

Buffalo Bills QB Josh Allen runs for a TD vs. the Miami Dolphins at Highmark Stadium in Orchard Park, New York.

Buffalo Bills QB Josh Allen runs for a TD vs. the Miami Dolphins at Highmark Stadium in Orchard Park, New York. (Gregory Fisher-USA TODAY Sports)

NFL Sunday 1 p.m. ET window (6 games)

Baltimore Ravens (3-1) at Pittsburgh Steelers (2-2)

Houston Texans (2-2) at Atlanta Falcons (2-2)

Carolina Panthers (0-4) at Detroit Lions (3-1)

Packers pass rusher Rashan Gary bears down on Detroit Lions QB Jared Goff at Lambeau Field in Green Bay, Wisconsin.

Packers pass rusher Rashan Gary bears down on Detroit Lions QB Jared Goff at Lambeau Field in Green Bay, Wisconsin. (Benny Sieu-USA TODAY Sports)

Tennessee Titans (2-2) at Indianapolis Colts (2-2)

New York Giants (1-2)* at Miami Dolphins (3-1)

The Giants still need to play the Seattle Seahawks on Monday Night Football in Week 4.

New Orleans Saints (2-2) at New England Patriots (1-3)

NFL Sunday 4 p.m. ET window (4 games)

Cincinnati Bengals (1-3) at Arizona Cardinals (1-3)

Titans edge rusher Harold Landry III sacks Cincinnati Bengals QB Joe Burrow at Nissan Stadium in Nashville, Tennessee.

Titans edge rusher Harold Landry III sacks Cincinnati Bengals QB Joe Burrow at Nissan Stadium in Nashville, Tennessee. (Wesley Hitt/Getty Images)

Philadelphia Eagles (4-0) at Los Angeles Rams (2-2)

New York Jets (1-3) at Denver Broncos (1-3)

Kansas City Chiefs (3-1) at Minnesota Vikings (1-3)

San Francisco 49ers RB Christian McCaffrey runs the ball against the Arizona Cardinals at Levi's Stadium in Santa Clara, California.

San Francisco 49ers RB Christian McCaffrey runs the ball against the Arizona Cardinals at Levi's Stadium in Santa Clara, California. (Michael Owens/Getty Images)

Sunday Night Football, 8:20 p.m. ET

Dallas Cowboys (3-1) at San Francisco 49ers (4-0)

Monday Night Football, 8:15 p.m. ET

Green Bay Packers (2-2) at Las Vegas Raiders (1-3)

Follow or fade my picks here, for not just the NFL but the NBA, NHL, PGA Tour, college football, and college hoops as well!

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Geoff Clark serves as OutKick’s sports betting guru. As a writer and host of OutKick Bets with Geoff Clark, he dives deep into the sports betting landscape and welcomes an array of sports betting personalities on his show to handicap America’s biggest sporting events. Previously, Clark was a writer/podcaster for USA TODAY's Sportsbook Wire website, handicapping all the major sports tentpoles with a major focus on the NFL, NBA and MLB. Clark graduated from St. John University.