NFL Week 3 Opening Betting Odds Include Rams-Eagles, Lions-Ravens, Chiefs-Giants

There are still two Monday Night Football games to play in NFL Week 2, but sportsbooks wasted no time releasing the odds for next week’s slate. Check out DraftKings' first-look moneylines, spreads, and totals for all 16 games in Week 3, highlighted by a rematch from the 2025 NFC Divisional Round between the Los Angeles Rams and reigning Super Bowl champion Philadelphia Eagles. 

NFL Week 3 Opening Lines 

The odds are courtesy of DraftKings as of 11:20 p.m. ET Sunday, September 14. 

Thursday Night Football 

Miami Dolphins (0-2) at Buffalo Bills (2-0) 

• Moneyline (ML): Miami (+550) | Buffalo (-800)
• Spread: Dolphins +12.5 (-110) | Bills -12.5 (-110)
• Total — 49.5 — Over (-110) | Under (-110)

Sunday, 1 p.m. ET (nine games) 

Green Bay Packers (2-0) at Cleveland Browns (0-2) 

• ML: Green Bay (-455) | Cleveland (+350)
• Spread: Packers -9.5 (-105) | Browns +8.5 (-115)
• Total — 42.5 — Over (-110) | Under (-110)

Las Vegas Raiders (1-0)* at Washington Commanders (1-1) 

*The Raiders still need to play the Los Angeles Chargers on Monday Night Football in NFL Week 2. 

Pittsburgh Steelers (1-1) at New England Patriots (1-1)  

• ML: Pittsburgh (-115) | New England (-105)
• Spread: Steelers -1.5 (-105) | Patriots +1.5 (-115)
• Total — 43.5 — Over (-105) | Under (-115)

Los Angeles Rams (2-0) at Philadelphia Eagles (2-0) 

• ML: LAR (+185) | Philadelphia (-225)
• Spread: Rams +4.5 (-110) | Eagles -4.5 (-110)
• Total — 45.5 — Over (-110) | Under (-110)

Indianapolis Colts (2-0) at Tennessee Titans (0-2) 

• ML: Indianapolis (-166) | Tennessee (+140)
• Spread: Colts -3 (-120) | Titans +3 (-100)
• Total — 43.5 — Over (-110) | Under (-110)

Colts QB Daniel Jones celebrates with Pat McAfee after beating the Denver Broncos at Lucas Oil Stadium in Indianapolis. (Photo credit: Grace Hollars/IndyStar-USA TODAY NETWORK via Imagn Images)

New York Jets (0-2) at Tampa Bay Buccaneers (1-0)**

• ML: NYJ (+260) | Tampa Bay (-325)
• Spread: Jets +7 (-108) | Buccaneers -7 (-112)
• Total — 44.5 — Over (-105) | Under (-115)

**Tampa Bay still needs to play the Houston Texans on Monday Night Football in NFL Week 2. 

Atlanta Falcons (1-1) at Carolina Panthers (0-2) 

• ML: Atlanta (-180) | Carolina (+150)
• Spread: Falcons -3.5 (-105) | Panthers +3.5 (-115)
• Total — 44.5 — Over (-110) | Under (-110)

Cincinnati Bengals (2-0) at Minnesota Vikings (1-1) 

• ML: Cincinnati (+170) | Minnesota (-205)
• Spread: Bengals +4.5 (-118) | Vikings -4.5 (-102)
• Total — 43.5 — Over (-110) | Under (-110)

Houston Texans (0-1)*** at Jacksonville Jaguars (1-1) 

***The Texans have to play the Buccaneers on Monday Night Football in NFL Week 2 still. 

Sunday, 4 p.m. ET (four games) 

New Orleans Saints (0-2) at Seattle Seahawks (1-1) 

• ML: New Orleans (+300) | Seattle (-380)
• Spread: Saints +7.5 (-110) | Seahawks -7.5 (-110)
• Total — 42.5 — Over (-110) | Under (-110)

Denver Broncos (1-1) at Los Angeles Chargers (1-0)****

• ML: Denver (+120) | LAC (-142)
• Spread: Broncos +2.5 (-110) | Chargers -2.5 (-110)
• Total — 45.5 — Over (-110) | Under (-110)

****The Chargers still have to play the Raiders on Monday Night Football in NFL Week 2. 

Dallas Cowboys (1-1) at Chicago Bears (0-2) 

• ML: Dallas (-102) | Chicago (-118)
• Spread: Cowboys +1.5 (-115) | Bears -1.5 (-105)
• Total — 49.5 — Over (-110) | Under (-110)

Dallas Cowboys QB Dak Prescott signals a first-down vs. the New York Giants during overtime at AT&T Stadium. (Photo Credit: Kevin Jairaj-Imagn Images)

Arizona Cardinals (2-0) at San Francisco 49ers (2-0)

• ML: Arizona (-118) | San Francisco (-102)
• Spread: Cardinals -1.5 (-105) | 49ers +1.5 (-115)
• Total — 43.5 — Over (-110) | Under (-110)

Sunday Night Football

Kansas City Chiefs (0-2) at New York Giants (0-2) 

• ML: Kansas City (-250) | NYG (+205)
• Spread: Chiefs -5.5 (-112) | Giants +5.5 (-108)
• Total — 42.5 — Over (-110) | Under (-110)

Monday Night Football

Detroit Lions (1-1) at Baltimore Ravens (1-1) 

• ML: Detroit (+210) | Baltimore (-258)
• Spread: Lions +6 (-112) | Ravens -6 (-108)
• Total — 51.5 — Over (-110) | Under (-110)

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