Special to Outkick The Coverage from OddsShark.com
The Louisville Cardinals have lost the two most recent meetings with the Florida State Seminoles both straight up and against the spread, with each decided by more than 10 points.
Louisville is coming off a 62-28 rout of the Syracuse Orange as 17-point chalk last Friday behind Jackson's five touchdowns, including four on the ground. The sophomore, who is also a Florida native, already has more than half the passing touchdowns he had all of last year, and his 318 yards rushing ranks him third nationally and is nearly double what Florida State's Dalvin Cook has so far. Cook entered the season as a top Heisman candidate and has rushed for 174 yards.
With the win and cover versus Syracuse, the Cards improved to 2-5 against the spread in their last seven ACC games while the Seminoles are 5-2 ATS in their past seven overall on the road.
Another intriguing Top 25 matchup pits the Oklahoma Sooners (1-1) against the Ohio State Buckeyes (2-0) in Norman. The Sooners would be ranked higher than the Buckeyes had they not been upset by the Houston Cougars 33-23 as 13-point favorites in their season opener.
Ohio State is 2.5-point road chalk here, riding an 18-game road winning streak that has seen the team go 12-6 ATS as well. Oklahoma puts its seven-game home winning streak on the line while going 4-3 ATS during that stretch.
Other college football Week 3 odds and betting trends:
Alabama (-10) at Ole Miss
Alabama is 10-2 SU in its last 12 games against Mississippi and 14-0 SU in its last 14 overall.
Ole Miss is 5-0 SU in its last five games against teams with winning records.
Michigan State at Notre Dame (-7.5)
Michigan State is 7-1-1 ATS in its last nine games on the road against Notre Dame.
Notre Dame is 8-2 ATS in its last 10 games against teams with winning records.
USC at Stanford (-6.5)
Southern Cal is 3-7 ATS in its last 10 games against Stanford.
Stanford is 11-1 SU and 10-2 ATS in its last 12 games against its conference.
Oregon at Nebraska (-3)
Oregon is 8-0 ATS in its last eight games on the road.
Nebraska is 23-4 SU in its last 27 games in September.
UCLA (-3.5) at BYU
UCLA is 0-6 ATS in its last six games after winning the previous game in a matchup.
BYU is 8-0 SU in its last eight games at home.