College Football Week 12 Opening Odds

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Right in the thick of the race for a berth in the College Football Playoff, the Notre Dame Fighting Irish can't afford to stumble this week when they take on the Boston College Eagles at Fenway Park as opening 16-point favorites. With no conference championship game available to boost their resume the Fighting Irish will have to continue to impress down the stretch, and they'll enter their game on Saturday at 9-1 straight up and 7-3 against the spread on the season. Notre Dame is 4-0 SU in its last four games against Boston College, but just 1-3 ATS.

Clemson, the top team in the AP Top 25, opened as a 29-point favorite at home against Wake Forest for Week 12, while No. 2 Ohio State opened as a 13-point favorite at home against Michigan State. According to the OddsShark College Football Database the Spartans are just 3-7 ATS in their last 10 games heading into this matchup.

Oklahoma State and Iowa join Clemson and Ohio State at a perfect 10-0 SU on the season heading into Week 12, and the Cowboys opened as a pick'em at home for their game against Baylor while the Hawkeyes opened as 17-point favorite at home against Purdue. The total has been an OVER result in four of Iowa's last five home games.

Check out the opening college football odds for the week below. For live odds and matchup reports on every game every day, head over to the college football betting section.

Toledo at Bowling Green -9 (TUE)

Ball State at Ohio -7 (TUE)

Central Michigan at Kent State +8.5 (WED)

Western Michigan at Northern Illinois -3.5 (WED)

East Carolina at UCF +17 (THU)

Louisiana Monroe at Texas State -5 (THU)

Cincinnati at South Florida +2.5 (FRI)

Air Force at Boise State -14.5 (FRI)

Houston at Connecticut OFF

Navy at Tulsa +9.5

LSU at Ole Miss -4.5

Louisville at Pittsburgh -1.5

Arizona at Arizona State OFF

USC at Oregon -2.5

UCLA at Utah +2

California at Stanford -12.5

TCU at Oklahoma OFF

Baylor at Oklahoma State EVEN

Purdue at Iowa -17

Indiana at Maryland -3

Illinois at Minnesota -7.5

Michigan State at Ohio State -13

Michigan at Penn State +5

Northwestern at Wisconsin -10.5

Rutgers at Army +5

West Virginia at Kansas +28

Iowa State at Kansas State -7

North Carolina at Virginia Tech +7.5

The Citadel at South Carolina OFF

Florida Atlantic at Florida -31

Memphis at Temple +1.5

North Texas at Middle Tennessee -24

Syracuse at NC State OFF

Georgia Tech at Miami -1

Miami-Ohio at Massachusetts -9

South Alabama at Georgia State -1

Western Kentucky at Florida Intl +14

Chattanooga at Florida State OFF

Fresno State at BYU -24.5

Nevada at Utah State -14

Old Dominion at Southern Mississippi -19.5

Louisiana Tech at UTEP +21.5

Buffalo at Akron -2.5

Wake Forest at Clemson -29

Duke at Virginia -2.5

Idaho at Auburn -32.5

Charleston Southern at Alabama OFF

New Mexico State at Louisiana Lafayette -14.5

Colorado State at New Mexico +2

Washington at Oregon State +16

Rice at Texas San Antonio EVEN

Mississippi State at Arkansas -3

Georgia at Southern Georgia -16

Tennessee at Missouri +9

Charlotte at Kentucky -24.5

Texas A&M at Vanderbilt +7.5

Boston College vs Notre Dame -16 (Fenway Park)

Tulane at SMU -3

San Diego State at UNLV +11

Colorado at Washington State -15.5

San Jose State at Hawaii +9

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Clay Travis is the founder of the fastest growing national multimedia platform, OutKick, that produces and distributes engaging content across sports and pop culture to millions of fans across the country. OutKick was created by Travis in 2011 and sold to the Fox Corporation in 2021. One of the most electrifying and outspoken personalities in the industry, Travis hosts OutKick The Show where he provides his unfiltered opinion on the most compelling headlines throughout sports, culture, and politics. He also makes regular appearances on FOX News Media as a contributor providing analysis on a variety of subjects ranging from sports news to the cultural landscape. Throughout the college football season, Travis is on Big Noon Kickoff for Fox Sports breaking down the game and the latest storylines. Additionally, Travis serves as a co-host of The Clay Travis and Buck Sexton Show, a three-hour conservative radio talk program syndicated across Premiere Networks radio stations nationwide. Previously, he launched OutKick The Coverage on Fox Sports Radio that included interviews and listener interactions and was on Fox Sports Bet for four years. Additionally, Travis started an iHeartRadio Original Podcast called Wins & Losses that featured in-depth conversations with the biggest names in sports. Travis is a graduate of George Washington University as well as Vanderbilt Law School. Based in Nashville, he is the author of Dixieland Delight, On Rocky Top, and Republicans Buy Sneakers Too.