NFL Week 2 Best Bets

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Find out if they will be able to rebound and avoid going 0-2 along with a couple other playoff-caliber teams.

49ers at Panthers (-13.5) (Sun, 1 pm ET) – Matchup Report

San Francisco looked great in a 28-0 rout of the Los Angeles Rams on Monday Night Football, but consider the opponent before you assume this is a good football team. Carolina is much better and will prove that by covering this huge number in its home opener. The Panthers were the only team in the league to go 8-0 straight up at home in 2015 with a 6-2 mark against the spread. They have also won 13 in a row there, and there’s no chance it won’t be 14 straight.

Buccaneers at Cardinals (-6.5) (Sun, 4:05 pm ET) – Matchup Report

Arizona did not play well offensively in a 23-21 loss to the New England Patriots on Sunday Night Football last week, but again consider the opponent. Tampa Bay is not New England, especially on the defensive side of the ball. The Cardinals should be able to exploit the Bucs through the air and on the ground in an easy double-digit victory. They have won five in a row after losing as favorites with a 6-1 ATS mark in their past seven following consecutive losses.

Colts (+6) at Broncos (Sun, 4:25 pm ET) – Matchup Report

The betting public loved the way Denver looked against Carolina, which is why you need to go the other way here and back Indianapolis in this spot. New quarterback Trevor Siemian cannot keep up with Andrew Luck and a disappointed Colts team on the scoreboard after their late rally came up just short in a 39-35 home loss to the Detroit Lions last week. Plus, Indy has won eight of the past nine meetings with the Broncos and gone a perfect 9-0 ATS during that stretch.

Written by Clay Travis

Clay Travis is the founder of the fastest growing national multimedia platform, OutKick, that produces and distributes engaging content across sports and pop culture to millions of fans across the country. OutKick was created by Travis in 2011 and sold to the Fox Corporation in 2021.

One of the most electrifying and outspoken personalities in the industry, Travis hosts OutKick The Show where he provides his unfiltered opinion on the most compelling headlines throughout sports, culture, and politics. He also makes regular appearances on FOX News Media as a contributor providing analysis on a variety of subjects ranging from sports news to the cultural landscape. Throughout the college football season, Travis is on Big Noon Kickoff for Fox Sports breaking down the game and the latest storylines.

Additionally, Travis serves as a co-host of The Clay Travis and Buck Sexton Show, a three-hour conservative radio talk program syndicated across Premiere Networks radio stations nationwide.

Previously, he launched OutKick The Coverage on Fox Sports Radio that included interviews and listener interactions and was on Fox Sports Bet for four years. Additionally, Travis started an iHeartRadio Original Podcast called Wins & Losses that featured in-depth conversations with the biggest names in sports.

Travis is a graduate of George Washington University as well as Vanderbilt Law School. Based in Nashville, he is the author of Dixieland Delight, On Rocky Top, and Republicans Buy Sneakers Too.