NCAA Tournament 2023 Opening Betting Lines

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March Madness, aka the greatest betting event on the sports calendar, tips off Tuesday with the First Four of the NCAA Tournament 2023 and the Round of 64 Thursday, March 16.

For sports bettors, March Madness is pretty much Christmas. Family and work duties get put on hold because there is wall-to-wall action from Thursday a.m. to Sunday p.m.

Our friends at DraftKings Sportsbook released odds for several NCAA Tournament 2023 games with the exception of one “First Four” game and the teams awaiting the winners of those games.

NCAA Tournament 2023: First Four in Dayton, Ohio

Tuesday, March 14th

South Region: 16-seed Southeast Missouri State vs. 16-seed Texas A&M-Corpus Christi

  • Moneyline: Southeast Missouri State (+160), Texas A&M-Corpus Christi (-190)
  • Spread: Southeast Missouri State +4 (-110), Texas A&M-Corpus Christi -4 (-110)
  • Total β€” 153.5 β€” Over: -110, Under: -110

Midwest Region: 11-seed Pittsburgh vs. 11-seed Mississippi State

  • Moneyline: Pittsburgh (+110), Mississippi State (-130)
  • Spread: Pittsburgh +2 (-110), Mississippi State -2 (-110)
  • Total β€” 131.5 β€” Over: -110, Under: -110

Wednesday, March 15th

East Region: 16-seed Texas Southern vs. 16-seed Fairleigh Dickinson

  • Off-the-board

West Region: 11-seed Nevada vs. 11-seed Arizona State

  • Moneyline: Nevada (+105), Arizona State (-125)
  • Spread: Nevada +1.5 (-110), Arizona State -1.5 (-110)
  • Total β€” 134.5 β€” Over: -110, Under: -110

NCAA Tournament 2023: Round of 64

Thursday, March 16th

Midwest Region in Kansas City, Missouri

1-seed Houston vs. 16-seed Northern Kentucky

  • Moneyline: Houston (-10000), Northern Kentucky (+2200)
  • Spread: Houston -20 (-110), Northern Kentucky +20 (-110)
  • Total β€” 121.5 β€” Over: -110, Under: -110

8-seed Iowa vs. 9-seed Auburn

  • Moneyline: Iowa (+100), Auburn (-120)
  • Spread: Iowa +1 (-110), Auburn -1 (-110)
  • Total β€” 153.5 β€” Over: -110, Under: -110
The Midwest Region in the NCAA Tournament 2023 courtesy of @MarchMadnessMBB on Twitter.

7-seed Texas A&M vs. 10-seed Penn State

  • Moneyline: Texas A&M (-155), Penn State (+135)
  • Spread: Texas A&M -3 (-110), Penn State +3 (-110)
  • Total β€” 134.5 β€” Over: -110, Under: -110

2-seed Texas vs. 15-seed Colgate

  • Moneyline: Texas (-1800), Colgate (+1000)
  • Spread: Texas -3 (-110), Colgate +14 (-110)
  • Total β€” 147 β€” Over: -110, Under: -110

South Region in Louisville, Kentucky

1-seed Alabama vs. 16-seed TBD

  • Off-the-board

8-seed Maryland vs. 9-seed West Virginia

  • Moneyline: Maryland (+120), West Virginia (-140)
  • Spread: Maryland +2.5 (-110), West Virginia -2.5 (-110)
  • Total β€” 140.5 β€” Over: -110, Under: -110

5-seed San Diego State vs. 12-seed Charleston

  • Moneyline: San Diego State (-205), Charleston (+175)
  • Spread: San Diego State -4.5 (-110), Charleston +5.5 (-110)
  • Total β€” 142 β€” Over: -110, Under: -110
The South Region in the NCAA Tournament 2023 courtesy of @MarchMadnessMBB on Twitter

4-seed Virginia vs. 13-seed Furman

  • Moneyline: Virginia (-245), Furman (+205)
  • Spread: Virginia -5 (-110), Furman +5 (-110)
  • Total β€” 132 β€” Over: -110, Under: -110

7-seed Missouri vs. 10-seed Utah State

  • Moneyline: Missouri (+110), Utah State (-130)
  • Spread: Missouri +1.5 (-110), Utah State -1.5 (-110)
  • Total β€” 159.5 β€” Over: -110, Under: -110

2-seed Arizona vs. 15-seed Princeton

  • Moneyline: Arizona (-2100), Princeton (+1100)
  • Spread: Arizona -13.5 (-110), Princeton +13.5 (-110)
  • Total β€” 154.5 β€” Over: -110, Under: -110

East Region in New York, NY

5-seed Duke vs. 12-seed Oral Roberts

  • Moneyline: Duke (-300), Oral Roberts (+250)
  • Spread: Duke -7 (-110), Oral Roberts +7 (-110)
  • Total β€” 144.5 β€” Over: -110, Under: -110
The Duke Blue Devils celebrate after winning the ACC Championship at Greensboro Coliseum in Greensboro, North Carolina.
The Duke Blue Devils celebrate after winning the ACC Championship at Greensboro Coliseum in Greensboro, North Carolina. (David Jensen/Icon Sportswire via Getty Images)

4-seed Tennessee vs. 13-seed Louisiana-Lafayette

  • Moneyline: Tennessee (-540), Louisiana-Lafayette (+420)
  • Spread: Tennessee -7 (-110), Louisiana-Lafayette +7 (-110)
  • Total β€” 136.5 β€” Over: -110, Under: -110

West Region in Las Vegas

1-seed Kansas vs. 16-seed Howard

  • Moneyline: Kansas (-20000), Howard (+3500)
  • Spread: Kansas -23 (-110), Howard +23 (-110)
  • Total β€” 149.5 β€” Over: -110, Under: -110

8-seed Arkansas vs. 9-seed Illinois

  • Moneyline: Arkansas (-135), Illinois (+120)
  • Spread: Arkansas -2.5 (-110), Illinois +2.5 (-110)
  • Total β€” 145.5 β€” Over: -110, Under: -110
The West Region in the NCAA Tournament 2023 courtesy of @MarchMadnessMBB on Twitter
The West Region in the NCAA Tournament 2023 courtesy of @MarchMadnessMBB on Twitter

7-seed Northwestern vs. 9-seed Boise State

  • Moneyline: Northwestern (+100), Boise State (-120)
  • Spread: Northwestern +1 (-110), Boise State -1 (-110)
  • Total β€” 128.5 β€” Over: -110, Under: -110

2-seed UCLA vs. 15-seed UNC Asheville

  • Moneyline: UCLA (-2800), UNC Asheville (-1300)
  • Spread: UCLA -18.5 (-110), UNC Asheville +18.5 (-110)
  • Total β€” 134.5 β€” Over: -110, Under: -110

Friday, March 17th

Midwest Region

5-seed Miami (Florida) vs. 12-seed Drake

  • Moneyline: Miami (-155), Drake (+135)
  • Spread: Miami -3 (-110), Drake +3 (-110)
  • Total β€” 147.5 β€” Over: -110, Under: -110

4-seed Indiana vs. 13-seed Kent State

  • Moneyline: Indiana (-215), Kent State (+185)
  • Spread: Indiana -4.5 (-110), Kent State +4.5 (-110)
  • Total β€” 144.5 β€” Over: -110, Under: -110
Kent State Golden Flashes accept the 2023 MAC Tournament trophy at Rocket Mortgage FieldHouse in Cleveland, Ohio.
Kent State Golden Flashes accept the 2023 MAC Tournament trophy at Rocket Mortgage FieldHouse in Cleveland, Ohio. (Frank Jansky/Icon Sportswire via Getty Images)

3-seed Xavier vs. 14-seed Kennesaw State

  • Moneyline: Xavier (-540), Kennesaw State (+420)
  • Spread: Xavier -12 (-110), Kennesaw State +12 (-110)
  • Total β€” 153.5 β€” Over: -110, Under: -110

6-seed Iowa State vs. 11-seed TBD

  • Off-the-board

South Region

6-seed Creighton vs. 11-seed NC State

  • Moneyline: Creighton (-225), NC State (+190)
  • Spread: Creighton -5 (-110), NC State +5 (-110)
  • Total β€” 147.5 β€” Over: -110, Under: -110

3-seed Baylor vs. 14-seed UC Santa Barbara

  • Moneyline: Baylor (-580), UC Santa Barbara (+440)
  • Spread: Baylor -11 (-110), UC Santa Barbara +11 (-110)
  • Total β€” 144.5 β€” Over: -110, Under: -110

East Region

1-seed Purdue vs. 16-seed TBD

  • Off-the-board

8-seed Memphis vs. 9-seed Florida Atlantic

  • Moneyline: Memphis (-580), Florida Atlantic (+440)
  • Spread: Memphis -11 (-110), Florida Atlantic +11 (-110)
  • Total β€” 144.5 β€” Over: -110, Under: -110

6-seed Kentucky vs. 11-seed Providence

  • Moneyline: Kentucky (-170), Providence (+145)
  • Spread: Kentucky -3.5 (-110), Providence +3.5 (-110)
  • Total β€” 145.5 β€” Over: -110, Under: -110
The East Region in the NCAA Tournament 2023 courtesy of @MarchMadnessMBB on Twitter

3-seed Kansas State vs. 14-seed Montana State

  • Moneyline: Kansas State (-450), Montana State (+360)
  • Spread: Kansas State -9 (-110), Montana State +9 (-110)
  • Total β€” 145.5 β€” Over: -110, Under: -110

7-seed Michigan State vs. 10-seed Southern California

  • Moneyline: Michigan State (-120), USC (+100)
  • Spread: Michigan State -1.5 (-110), USC +1.5 (-110)
  • Total β€” 137.5 β€” Over: -110, Under: -110
The Marquette Golden Eagles pose with the trophy after defeating the Xavier Musketeers in the Big East Basketball Tournament Championship at Madison Square Garden.
The Marquette Golden Eagles pose with the trophy after defeating the Xavier Musketeers in the Big East Basketball Tournament Championship at Madison Square Garden. (Sarah Stier/Getty Images)

2-seed Marquette vs. 15-seed Vermont

  • Moneyline: Marquette (-645), Vermont (+480)
  • Spread: Marquette -11.5 (-110), Vermont +11.5 (-110)
  • Total β€” 146 β€” Over: -110, Under: -110

West Region

5-seed Saint Mary’s vs. 12-seed VCU

  • Moneyline: Saint Mary’s (-200), VCU (+170)
  • Spread: Saint Mary’s -3.5 (-110), VCU +3.5 (-110)
  • Total β€” 122.5 β€” Over: -110, Under: -110

3-seed Gonzaga vs. 14-seed Grand Canyon

  • Moneyline: Gonzaga (-2800), Grand Canyon (+1300)
  • Spread: Gonzaga -15 (-110), Grand Canyon +15 (-110)
  • Total β€” 156 β€” Over: -110, Under: -110
Gonzaga Bulldogs big Drew Timme cuts down a net after Gonzaga's 77-51 victory over the Saint Mary's Gaels to win the West Coast Conference championship at the Orleans Arena in Las Vegas.
Gonzaga Bulldogs big Drew Timme cuts down a net after Gonzaga wins the West Coast Conference championship at the Orleans Arena in Las Vegas. (Ethan Miller/Getty Images)

4-seed UConn vs. 13-seed Iona

  • Moneyline: UConn (-500), Iona (+400)
  • Spread: UConn -9.5 (-110), Iona +9.5 (-110)
  • Total β€” 144 β€” Over: -110, Under: -110

6-seed TCU vs. 11-seed TBD

  • Off-the-board

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Written by Geoff Clark

Geoff Clark serves as OutKick’s sports betting guru. As a writer and host of OutKick Bets with Geoff Clark, he dives deep into the sports betting landscape and welcomes an array of sports betting personalities on his show to handicap America’s biggest sporting events.

Previously, Clark was a writer/podcaster for USA TODAY's Sportsbook Wire website, handicapping all the major sports tentpoles with a major focus on the NFL, NBA and MLB.

Clark graduated from St. John University.

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