College Football Week 6 Opening Odds

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Ohio State is a 28.5-point favorite on the opening Week 6 betting lines at sportsbooks monitored by for their home game against Maryland on Saturday, one week after they got past Indiana 34-27 on the road but failed to cover the 21.5-point spread.

That means Ohio State is 5-0 straight up but 1-4 against the spread so far this season, and they head into Saturday’s game at 0-5 ATS in their last five games at home according to the OddsShark College Football Database. Maryland, though, is 2-5 both SU and ATS in its last seven games.

Also on Saturday, the Oklahoma Sooners are 13.5-point favorites against the Texas Longhorns for their annual Red River Rivalry clash at the Cotton Bowl. Oklahoma beat Texas 31-26 but failed to cover the 16.5-point spread in this matchup last year. The Longhorns are 1-6 both SU and ATS in their last seven games, and they were blasted 50-7 by TCU as a 14.5-point underdog on the weekend.

Elsewhere, Notre Dame opened as a 16-point home favorite against Navy for Saturday at the sportsbooks, with the OVER having paid off for totals bettors in each of their last five matchups. Clemson opened as a 7.5-point home favorite against Georgia Tech, Utah opened as a 7-point home favorite against California, and Michigan State opened as a 17-point road favorite against Rutgers.

Check out the opening college football odds for the week. Live odds and matchup reports on every game every day, head over to the college football betting section.

SMU at Houston -21 (THU)

Washington at USC -17 (THU)

Southern Mississippi at Marshall -6.5 (FRI)

NC State at Virginia Tech -2 (FRI)

Duke at Army +11

New Mexico State at Ole Miss -43

LSU at South Carolina +13

UTEP at Florida International -13

Middle Tennessee at Western Kentucky -7.5

Illinois at Iowa -10

Baylor at Kansas +38

Oklahoma vs Texas +13.5

Maryland at Ohio State -28.5

Indiana at Penn State -8

Tulane at Temple -14.5

Central Michigan at Western Michigan -5

Virginia at Pittsburgh -10

Miami-Ohio at Ohio -17.5

Massachusetts at Bowling Green -13.5

Rice at Florida Atlantic -1.5

Wake Forest at Boston College -9

Akron at Eastern Michigan +9

Kent State at Toledo -15.5

Appalachian State at Georgia State +18

Ball State at Northern Illinois -10.5

Georgia Tech at Clemson -7.5

Georgia at Tennessee +2.5

Syracuse at South Florida -5

Navy at Notre Dame -16

Northwestern at Michigan -10

Wisconsin at Nebraska -1

Minnesota at Purdue +2.5

Iowa State at Texas Tech -11.5

Connecticut at UCF -3

Oregon State at Arizona -12.5

Troy at Mississippi State -31.5

Washington State at Oregon -20

Louisiana Monroe at Tulsa -7

Boise State at Colorado State +12

Texas State at Louisiana Lafayette -5

New Mexico at Nevada -6

Arkansas at Alabama -16

Louisiana Tech at Texas San Antonio +11.5

Oklahoma State at West Virginia -6

TCU at Kansas State +7

Florida at Missouri +3.5

East Carolina at BYU -8.5

Miami at Florida State -9

Michigan State at Rutgers +17

San Jose State at UNLV EVEN

Colorado at Arizona State -12.5

California at Utah -7

Wyoming at Air Force -21.5

Utah State at Fresno State +10

San Diego State at Hawaii +2

Written by Clay Travis

OutKick founder, host and author. He's presently banned from appearing on both CNN and ESPN because he’s too honest for both.