College Football Week 6 Opening Odds

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Ohio State is a 28.5-point favorite on the opening Week 6 betting lines at sportsbooks monitored by for their home game against Maryland on Saturday, one week after they got past Indiana 34-27 on the road but failed to cover the 21.5-point spread.

That means Ohio State is 5-0 straight up but 1-4 against the spread so far this season, and they head into Saturday’s game at 0-5 ATS in their last five games at home according to the OddsShark College Football Database. Maryland, though, is 2-5 both SU and ATS in its last seven games.

Also on Saturday, the Oklahoma Sooners are 13.5-point favorites against the Texas Longhorns for their annual Red River Rivalry clash at the Cotton Bowl. Oklahoma beat Texas 31-26 but failed to cover the 16.5-point spread in this matchup last year. The Longhorns are 1-6 both SU and ATS in their last seven games, and they were blasted 50-7 by TCU as a 14.5-point underdog on the weekend.

Elsewhere, Notre Dame opened as a 16-point home favorite against Navy for Saturday at the sportsbooks, with the OVER having paid off for totals bettors in each of their last five matchups. Clemson opened as a 7.5-point home favorite against Georgia Tech, Utah opened as a 7-point home favorite against California, and Michigan State opened as a 17-point road favorite against Rutgers.

Check out the opening college football odds for the week. Live odds and matchup reports on every game every day, head over to the college football betting section.

SMU at Houston -21 (THU)

Washington at USC -17 (THU)

Southern Mississippi at Marshall -6.5 (FRI)

NC State at Virginia Tech -2 (FRI)

Duke at Army +11

New Mexico State at Ole Miss -43

LSU at South Carolina +13

UTEP at Florida International -13

Middle Tennessee at Western Kentucky -7.5

Illinois at Iowa -10

Baylor at Kansas +38

Oklahoma vs Texas +13.5

Maryland at Ohio State -28.5

Indiana at Penn State -8

Tulane at Temple -14.5

Central Michigan at Western Michigan -5

Virginia at Pittsburgh -10

Miami-Ohio at Ohio -17.5

Massachusetts at Bowling Green -13.5

Rice at Florida Atlantic -1.5

Wake Forest at Boston College -9

Akron at Eastern Michigan +9

Kent State at Toledo -15.5

Appalachian State at Georgia State +18

Ball State at Northern Illinois -10.5

Georgia Tech at Clemson -7.5

Georgia at Tennessee +2.5

Syracuse at South Florida -5

Navy at Notre Dame -16

Northwestern at Michigan -10

Wisconsin at Nebraska -1

Minnesota at Purdue +2.5

Iowa State at Texas Tech -11.5

Connecticut at UCF -3

Oregon State at Arizona -12.5

Troy at Mississippi State -31.5

Washington State at Oregon -20

Louisiana Monroe at Tulsa -7

Boise State at Colorado State +12

Texas State at Louisiana Lafayette -5

New Mexico at Nevada -6

Arkansas at Alabama -16

Louisiana Tech at Texas San Antonio +11.5

Oklahoma State at West Virginia -6

TCU at Kansas State +7

Florida at Missouri +3.5

East Carolina at BYU -8.5

Miami at Florida State -9

Michigan State at Rutgers +17

San Jose State at UNLV EVEN

Colorado at Arizona State -12.5

California at Utah -7

Wyoming at Air Force -21.5

Utah State at Fresno State +10

San Diego State at Hawaii +2

Written by Clay Travis

Clay Travis is the founder of the fastest growing national multimedia platform, OutKick, that produces and distributes engaging content across sports and pop culture to millions of fans across the country. OutKick was created by Travis in 2011 and sold to the Fox Corporation in 2021.

One of the most electrifying and outspoken personalities in the industry, Travis hosts OutKick The Show where he provides his unfiltered opinion on the most compelling headlines throughout sports, culture, and politics. He also makes regular appearances on FOX News Media as a contributor providing analysis on a variety of subjects ranging from sports news to the cultural landscape. Throughout the college football season, Travis is on Big Noon Kickoff for Fox Sports breaking down the game and the latest storylines.

Additionally, Travis serves as a co-host of The Clay Travis and Buck Sexton Show, a three-hour conservative radio talk program syndicated across Premiere Networks radio stations nationwide.

Previously, he launched OutKick The Coverage on Fox Sports Radio that included interviews and listener interactions and was on Fox Sports Bet for four years. Additionally, Travis started an iHeartRadio Original Podcast called Wins & Losses that featured in-depth conversations with the biggest names in sports.

Travis is a graduate of George Washington University as well as Vanderbilt Law School. Based in Nashville, he is the author of Dixieland Delight, On Rocky Top, and Republicans Buy Sneakers Too.