College Football Week 5 Opening Odds

Videos by OutKick

Special to Outkick The Coverage from

The Alabama Crimson Tide and the Notre Dame Fighting Irish both opened as part of pick’em matchups on the Week 5 college football odds at sportsbooks monitored by, but the schools find themselves as small betting underdogs after the early line moves.

Alabama, a favorite in its last 72 games, opened as a pick’em on the road against Georgia, but now sits as a 1.5-point road underdog. Notre Dame, a perfect 4-0 SU on the season, finds itself as a 2.5-point road underdog after opening in a pick’em matchup against Clemson.

The Fighting Irish are 0-3 against the spread in their last three games on the road according to the OddsShark College Football Database, while the Tigers are 10-1 SU in their last 11 home games in the month of October.

Meanwhile, big spreads for Week 5 include Michigan State -24.5 at home to Purdue, Florida State -18 on the road at Wake Forest, and LSU -45 at home to Eastern Michigan. As well, top-ranked Ohio State opened as a 17.5-point road favorite at Indiana.

The Buckeyes are perfect at 15-0 SU in their last 15 games against Indiana, and 18-0 SU in their last 18 games overall. The Hoosiers, though, will be looking to build on a solid ATS run on Saturday as they’re 5-1 ATS in their last six games.

Check out the opening college football odds for the week. For live odds and matchup reports on every game every day, head over to the college football betting section.

Miami at Cincinnati +5 (THU)

Memphis at South Florida +10.5 (FRI)

Temple at Charlotte +23.5 (FRI)

Connecticut at BYU -3.5 (FRI)

Arizona at Stanford OFF

Arizona at State UCLA -13

Pittsburgh at Virginia Tech -4.5

South Carolina at Missouri -3.5

Purdue at Michigan State -24.5

Minnesota at Northwestern -6.5

Iowa at Wisconsin -8

Army at Penn State OFF

Kansas at Iowa State -14.5

West Virginia at Oklahoma -7.5

Texas at TCU -18.5

UCF at Tulane EVEN

Houston at Tulsa +9.5

Louisville at NC State -5

Ohio at Akron +4

Toledo at Ball State +9.5

Washington State at California -13.5

Florida Intl at Massachusetts EVEN

Northern Illinois at Central Michigan +2.5

Wyoming at Appalachian State -17.5

Liberty at Georgia State OFF

Air Force at Navy -6

Bowling Green at Buffalo +6.5

Miami-Ohio at Kent State -10.5

Boston College at Duke -7

Florida State at Wake Forest +18

North Carolina at Georgia Tech -10.5

Alabama at Georgia EVEN

Texas Tech vs Baylor -15.5

Nebraska at Illinois +7.5

Ohio State at Indiana +17.5

Old Dominion at Marshall -18

Western Kentucky at Rice +5

Kansas State at Oklahoma State -3.5

San Jose State at Auburn -20.5

East Carolina at SMU +6.5

Idaho at Arkansas State -20.5

Georgia Southern at Louisiana Monroe +7.5

Colorado State at Utah State -7

UNLV at Nevada -11.5

South Alabama at Troy -3

Ole Miss at Florida +6.5

Arkansas at Tennessee -7.5

Eastern Michigan at LSU -45

Vanderbilt at Middle Tennessee -4.5

North Texas at Southern Mississippi -13.5

Louisiana Lafayette at Louisiana Tech -16

Mississippi State at Texas A&M -6

Eastern Kentucky at Kentucky OFF

Notre Dame at Clemson EVEN

Texas San Antonio at UTEP +2

Michigan at Maryland +12

New Mexico State at New Mexico -14

Oregon at Colorado +12

Hawaii at Boise State -23.5

Fresno State at San Diego State -9.5

Written by Clay Travis

Clay Travis is the founder of the fastest growing national multimedia platform, OutKick, that produces and distributes engaging content across sports and pop culture to millions of fans across the country. OutKick was created by Travis in 2011 and sold to the Fox Corporation in 2021.

One of the most electrifying and outspoken personalities in the industry, Travis hosts OutKick The Show where he provides his unfiltered opinion on the most compelling headlines throughout sports, culture, and politics. He also makes regular appearances on FOX News Media as a contributor providing analysis on a variety of subjects ranging from sports news to the cultural landscape. Throughout the college football season, Travis is on Big Noon Kickoff for Fox Sports breaking down the game and the latest storylines.

Additionally, Travis serves as a co-host of The Clay Travis and Buck Sexton Show, a three-hour conservative radio talk program syndicated across Premiere Networks radio stations nationwide.

Previously, he launched OutKick The Coverage on Fox Sports Radio that included interviews and listener interactions and was on Fox Sports Bet for four years. Additionally, Travis started an iHeartRadio Original Podcast called Wins & Losses that featured in-depth conversations with the biggest names in sports.

Travis is a graduate of George Washington University as well as Vanderbilt Law School. Based in Nashville, he is the author of Dixieland Delight, On Rocky Top, and Republicans Buy Sneakers Too.