College Football Week 5 Picks

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Special to Outkick The Coverage from OddsShark.com

The winner of that matchup will stake its claim as the conference's best team and put itself in prime position for the College Football Playoff.

Here's a look at three top betting picks for Week 5 of the college football season:

Notre Dame (-11) vs. Syracuse (Sat, at 12 p.m. ET) - Matchup Report

This game does not have much luster as far as the national rankings go, but the Fighting Irish (1-3) find themselves in a bad spot and may just be a bad team. The Orange (2-2) can score with just about any team in the country, but how much is always the question. Syracuse has covered the spread in three of the past four meetings and will stay within double digits in this game at MetLife Stadium.

Wisconsin at Michigan (-10.5) (Sat, 3:30 p.m. ET) - Matchup Report

The Badgers are fresh off a dominant 30-6 road upset win at Michigan State, so the odds of them winning twice in as many weeks within the state seem very long. The Wolverines are at a completely different level when compared to the Spartans, and Wisconsin will find that out the hard way. Michigan is 9-2 straight up in its last 11 versus teams with winning records, and Jim Harbaugh's squad will rise to the occasion and win this one by more than two touchdowns.

Louisville (-2) at Clemson (Sat, 8 p.m. ET) - Matchup Report

The Tigers bring an 18-game home winning streak into this game against the Cardinals -- going 10-8 against the spread -- and they were not underdogs once during that stretch. While Louisville has looked mighty impressive this season behind Jackson, Clemson has won the past two meetings, including a 20-17 road victory last season, and will be very motivated to prove who is the better team and the better player (Watson) in pulling off the small upset.

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Clay Travis is the founder of the fastest growing national multimedia platform, OutKick, that produces and distributes engaging content across sports and pop culture to millions of fans across the country. OutKick was created by Travis in 2011 and sold to the Fox Corporation in 2021. One of the most electrifying and outspoken personalities in the industry, Travis hosts OutKick The Show where he provides his unfiltered opinion on the most compelling headlines throughout sports, culture, and politics. He also makes regular appearances on FOX News Media as a contributor providing analysis on a variety of subjects ranging from sports news to the cultural landscape. Throughout the college football season, Travis is on Big Noon Kickoff for Fox Sports breaking down the game and the latest storylines. Additionally, Travis serves as a co-host of The Clay Travis and Buck Sexton Show, a three-hour conservative radio talk program syndicated across Premiere Networks radio stations nationwide. Previously, he launched OutKick The Coverage on Fox Sports Radio that included interviews and listener interactions and was on Fox Sports Bet for four years. Additionally, Travis started an iHeartRadio Original Podcast called Wins & Losses that featured in-depth conversations with the biggest names in sports. Travis is a graduate of George Washington University as well as Vanderbilt Law School. Based in Nashville, he is the author of Dixieland Delight, On Rocky Top, and Republicans Buy Sneakers Too.