College Football Week 3 Best Bets

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And each of them will try to stay perfect by earning wins as road favorites. The Alabama Crimson Tide and Ohio State Buckeyes both have hopes of making it back to the College Football Playoff field at the end of the season while the Florida State Seminoles are seeking their first-ever appearance but second national championship in four years. Will any of them get upset, or will they all prevail on Saturday?

Florida State (-2.5) at Louisville (Sat, 12 pm ET) – Matchup Report

Two top Heisman Trophy contenders will meet when Florida State running back Dalvin Cook visits Louisville and quarterback Lamar Jackson, who may be the favorite to win the award at this point. Jackson is putting up video game numbers for the Cardinals so far, but this will likely be his biggest challenge of the season. The Seminoles have won 28 of their last 30 ACC games straight up and have gone 5-2 against the spread in their past seven on the road overall. Look for Florida State’s defense to be the difference as Jackson gets held in check.

Alabama (-11) at Ole Miss (Sat, 3:30 pm ET) – Matchup Report

The Crimson Tide have rolled to a 10-2 mark in the past 12 meetings with the Rebels, although one of the losses took place last year at home 43-37 as a nine-point favorite. That was Alabama’s last setback, as the team has won 14 in a row since then with a 9-5 record ATS. Ole Miss blew a big lead against Florida State in losing its opener 45-34, and the betting public will have that stuck in their minds heading into this SEC showdown. Take advantage of the inflated line and back the Rebels to hang tough and possibly pull off the upset again.

Ohio State (-2) at Oklahoma (Sat, at 7:30 pm ET) – Matchup Report

Two high-profile head coaches will match wits in Norman, as Urban Meyer tries to win his 19th straight road game for the Buckeyes. Bob Stoops and the Sooners will be ready for them and have won seven in a row SU at home, although they have not been home underdogs since 2000. Oklahoma has won three consecutive times as a home dog according to the OddsShark College Football Database and will make it four here with a small upset victory.


Written by Clay Travis

OutKick founder, host and author. He's presently banned from appearing on both CNN and ESPN because he’s too honest for both.