College Football Week 3 Best Bets

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And each of them will try to stay perfect by earning wins as road favorites. The Alabama Crimson Tide and Ohio State Buckeyes both have hopes of making it back to the College Football Playoff field at the end of the season while the Florida State Seminoles are seeking their first-ever appearance but second national championship in four years. Will any of them get upset, or will they all prevail on Saturday?

Florida State (-2.5) at Louisville (Sat, 12 pm ET) – Matchup Report

Two top Heisman Trophy contenders will meet when Florida State running back Dalvin Cook visits Louisville and quarterback Lamar Jackson, who may be the favorite to win the award at this point. Jackson is putting up video game numbers for the Cardinals so far, but this will likely be his biggest challenge of the season. The Seminoles have won 28 of their last 30 ACC games straight up and have gone 5-2 against the spread in their past seven on the road overall. Look for Florida State’s defense to be the difference as Jackson gets held in check.

Alabama (-11) at Ole Miss (Sat, 3:30 pm ET) – Matchup Report

The Crimson Tide have rolled to a 10-2 mark in the past 12 meetings with the Rebels, although one of the losses took place last year at home 43-37 as a nine-point favorite. That was Alabama’s last setback, as the team has won 14 in a row since then with a 9-5 record ATS. Ole Miss blew a big lead against Florida State in losing its opener 45-34, and the betting public will have that stuck in their minds heading into this SEC showdown. Take advantage of the inflated line and back the Rebels to hang tough and possibly pull off the upset again.

Ohio State (-2) at Oklahoma (Sat, at 7:30 pm ET) – Matchup Report

Two high-profile head coaches will match wits in Norman, as Urban Meyer tries to win his 19th straight road game for the Buckeyes. Bob Stoops and the Sooners will be ready for them and have won seven in a row SU at home, although they have not been home underdogs since 2000. Oklahoma has won three consecutive times as a home dog according to the OddsShark College Football Database and will make it four here with a small upset victory.


Written by Clay Travis

Clay Travis is the founder of the fastest growing national multimedia platform, OutKick, that produces and distributes engaging content across sports and pop culture to millions of fans across the country. OutKick was created by Travis in 2011 and sold to the Fox Corporation in 2021.

One of the most electrifying and outspoken personalities in the industry, Travis hosts OutKick The Show where he provides his unfiltered opinion on the most compelling headlines throughout sports, culture, and politics. He also makes regular appearances on FOX News Media as a contributor providing analysis on a variety of subjects ranging from sports news to the cultural landscape. Throughout the college football season, Travis is on Big Noon Kickoff for Fox Sports breaking down the game and the latest storylines.

Additionally, Travis serves as a co-host of The Clay Travis and Buck Sexton Show, a three-hour conservative radio talk program syndicated across Premiere Networks radio stations nationwide.

Previously, he launched OutKick The Coverage on Fox Sports Radio that included interviews and listener interactions and was on Fox Sports Bet for four years. Additionally, Travis started an iHeartRadio Original Podcast called Wins & Losses that featured in-depth conversations with the biggest names in sports.

Travis is a graduate of George Washington University as well as Vanderbilt Law School. Based in Nashville, he is the author of Dixieland Delight, On Rocky Top, and Republicans Buy Sneakers Too.