College Football Week 12 Opening Odds

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Right in the thick of the race for a berth in the College Football Playoff, the Notre Dame Fighting Irish can’t afford to stumble this week when they take on the Boston College Eagles at Fenway Park as opening 16-point favorites. With no conference championship game available to boost their resume the Fighting Irish will have to continue to impress down the stretch, and they’ll enter their game on Saturday at 9-1 straight up and 7-3 against the spread on the season. Notre Dame is 4-0 SU in its last four games against Boston College, but just 1-3 ATS.

Clemson, the top team in the AP Top 25, opened as a 29-point favorite at home against Wake Forest for Week 12, while No. 2 Ohio State opened as a 13-point favorite at home against Michigan State. According to the OddsShark College Football Database the Spartans are just 3-7 ATS in their last 10 games heading into this matchup.

Oklahoma State and Iowa join Clemson and Ohio State at a perfect 10-0 SU on the season heading into Week 12, and the Cowboys opened as a pick’em at home for their game against Baylor while the Hawkeyes opened as 17-point favorite at home against Purdue. The total has been an OVER result in four of Iowa’s last five home games.

Check out the opening college football odds for the week below. For live odds and matchup reports on every game every day, head over to the college football betting section.

Toledo at Bowling Green -9 (TUE)

Ball State at Ohio -7 (TUE)

Central Michigan at Kent State +8.5 (WED)

Western Michigan at Northern Illinois -3.5 (WED)

East Carolina at UCF +17 (THU)

Louisiana Monroe at Texas State -5 (THU)

Cincinnati at South Florida +2.5 (FRI)

Air Force at Boise State -14.5 (FRI)

Houston at Connecticut OFF

Navy at Tulsa +9.5

LSU at Ole Miss -4.5

Louisville at Pittsburgh -1.5

Arizona at Arizona State OFF

USC at Oregon -2.5

UCLA at Utah +2

California at Stanford -12.5

TCU at Oklahoma OFF

Baylor at Oklahoma State EVEN

Purdue at Iowa -17

Indiana at Maryland -3

Illinois at Minnesota -7.5

Michigan State at Ohio State -13

Michigan at Penn State +5

Northwestern at Wisconsin -10.5

Rutgers at Army +5

West Virginia at Kansas +28

Iowa State at Kansas State -7

North Carolina at Virginia Tech +7.5

The Citadel at South Carolina OFF

Florida Atlantic at Florida -31

Memphis at Temple +1.5

North Texas at Middle Tennessee -24

Syracuse at NC State OFF

Georgia Tech at Miami -1

Miami-Ohio at Massachusetts -9

South Alabama at Georgia State -1

Western Kentucky at Florida Intl +14

Chattanooga at Florida State OFF

Fresno State at BYU -24.5

Nevada at Utah State -14

Old Dominion at Southern Mississippi -19.5

Louisiana Tech at UTEP +21.5

Buffalo at Akron -2.5

Wake Forest at Clemson -29

Duke at Virginia -2.5

Idaho at Auburn -32.5

Charleston Southern at Alabama OFF

New Mexico State at Louisiana Lafayette -14.5

Colorado State at New Mexico +2

Washington at Oregon State +16

Rice at Texas San Antonio EVEN

Mississippi State at Arkansas -3

Georgia at Southern Georgia -16

Tennessee at Missouri +9

Charlotte at Kentucky -24.5

Texas A&M at Vanderbilt +7.5

Boston College vs Notre Dame -16 (Fenway Park)

Tulane at SMU -3

San Diego State at UNLV +11

Colorado at Washington State -15.5

San Jose State at Hawaii +9

Written by Clay Travis

OutKick founder, host and author. He's presently banned from appearing on both CNN and ESPN because he’s too honest for both.