College Football Week 10 Opening Odds

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The Ohio State Buckeyes won’t have starting quarterback J.T. Barrett on the field this weekend due to a team-imposed suspension, but that hasn’t stopped sportsbooks monitored by from opening them as over three-touchdown favorites for their matchup with the Minnesota Golden Gophers.

The opening college football odds for Week 10 have the Buckeyes pegged as 23-point favorites against the Golden Gophers as they look to improve on the 8-0 straight up (but just 3-5 against the spread) start to the season that continues to have them atop the AP Top 25.

The Buckeyes have won nine straight games against the Golden Gophers dating back to 2001 according to the OddsShark College Football Database, covering the spread in six of those contests. However, Minnesota has shown some ATS life in the series recently, covering in three of their last five meetings including last season when they fell 31-24 as an 11.5-point home underdog on the betting lines.

Elsewhere this week No. 2 Baylor opened as an 18.5-point road favorite for its game against Kansas State on Thursday night, while No. 4 LSU opened as a 7-point road underdog for its game against another ranked team, No. 7 Alabama. No. 3 Clemson hosts No. 17 Florida State on Saturday, with that game OFF the board early in the week due to injuries to Seminoles quarterback Everett Golson (head) and running back Dalvin Cook (ankle).

And in the other marquee matchup for the week ahead, No. 5 TCU opened as a 5-point road favorite against No. 12 Oklahoma State. The Horned Frogs demolished the Cowboys in their meeting last season, beating them 42-9 at home as a 10.5-point favorite.

Check out the rest of the opening college football odds for the week below. For live odds and matchup reports on every game every day, head over to the college football betting section.

Northern Illinois at Toledo -7 (TUE)

Ohio at Bowling Green -13.5 (WED)

Buffalo at Kent State +3 (THU)

Ball State at Western Michigan -13.5 (THU)

Arkansas State at Appalachian State (THU)

Baylor at Kansas State +18.5 (THU)

Mississippi State at Missouri OFF (THU)

Nevada at Fresno State +3.5 (THU)

Temple at SMU +11.5 (FRI)

Rice at UTEP +6.5 (FRI)

BYU at San Jose State +12 (FRI)

Cincinnati at Houston -9

Navy at Memphis -8.5

Akron at Massachusetts -1.5

Penn State at Northwestern -2

Iowa at Indiana +8

Rutgers at Michigan -21.5

NC State at Boston College +1

Duke at North Carolina -8

Texas Tech at West Virginia -7

Notre Dame at Pittsburgh +7.5

Vanderbilt at Florida -19

Kentucky at Georgia -17

Illinois at Purdue +1.5

Charlotte at Florida Intl -19

Florida Atlantic at Western Kentucky -22

UCF at Tulsa -11

Syracuse at Louisville -12

Stanford at Colorado +16

Louisiana Lafayette at Georgia State +6.5

Eastern Michigan at Miami-Ohio -6.5

Idaho at South Alabama -5.5

Colorado State at Wyoming OFF

Virginia at Miami OFF

Marshall at Middle Tennessee -2

Arizona State at Washington State +1

Florida State at Clemson OFF

Arkansas at Ole Miss -11

Army at Air Force -17.5

North Texas at Louisiana Tech -30

Wisconsin at Maryland +13

TCU at Oklahoma State +5

Utah State at New Mexico +14.5

Louisiana Monroe at Troy -5

New Mexico State at Texas State -13

Connecticut at Tulane OFF

South Carolina at Tennessee -15

UCLA at Oregon State +15.5

Hawaii at UNLV -6

Iowa State at Oklahoma -26

Michigan State at Nebraska OFF

Old Dominion at Texas San Antonio -12.5

Utah at Washington EVEN

Auburn at Texas A&M -8.5

South Florida at East Carolina -3

LSU at Alabama -7

Minnesota at Ohio State -23

Kansas at Texas -31.5

California at Oregon -7.5

Arizona at USC -16.5

Written by Clay Travis

Clay Travis is the founder of the fastest growing national multimedia platform, OutKick, that produces and distributes engaging content across sports and pop culture to millions of fans across the country. OutKick was created by Travis in 2011 and sold to the Fox Corporation in 2021.

One of the most electrifying and outspoken personalities in the industry, Travis hosts OutKick The Show where he provides his unfiltered opinion on the most compelling headlines throughout sports, culture, and politics. He also makes regular appearances on FOX News Media as a contributor providing analysis on a variety of subjects ranging from sports news to the cultural landscape. Throughout the college football season, Travis is on Big Noon Kickoff for Fox Sports breaking down the game and the latest storylines.

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Previously, he launched OutKick The Coverage on Fox Sports Radio that included interviews and listener interactions and was on Fox Sports Bet for four years. Additionally, Travis started an iHeartRadio Original Podcast called Wins & Losses that featured in-depth conversations with the biggest names in sports.

Travis is a graduate of George Washington University as well as Vanderbilt Law School. Based in Nashville, he is the author of Dixieland Delight, On Rocky Top, and Republicans Buy Sneakers Too.